Systemic pharmacokinetic/pharmacodynamic analysis of intravitreal aflibercept injection in patients with retinal diseases.

Peter K KaiserLaurent KodjikianJean-Francois KorobelnikJulia WinklerAlbert TorriOliver ZeitzRobert VittiCristiane AhlersTorsten ZimmermannA Thomas DicioccioJoachim Höchel

Published in: BMJ open ophthalmology (2019)

IAI administration was not associated with systemic effects in patients with nAMD or DME as measured by blood pressure or intrarenal function, two known pharmacologically relevant effects of anti-vascular endothelial growth factor.

Keyphrases

vascular endothelial growth factor
blood pressure
endothelial cells
diabetic retinopathy
optical coherence tomography
age related macular degeneration
hypertensive patients
ultrasound guided
type diabetes
metabolic syndrome
adipose tissue
blood glucose