Effects of somatostatin receptor type 2 antagonism during insulin-induced hypoglycaemia in male rats with prediabetes.

Emily G HoffmanNinoschka C D'SouzaJulian AikenSara AtherleyRichard LigginsMichael C Riddell

Published in: Diabetes, obesity & metabolism (2023)

Treatment with an SSTR2a increases glucagon responsiveness and delays the onset of insulin-induced hypoglycaemia in this rat model of pre-T2D where only a modest deficiency in glucagon counterregulation exists.

Keyphrases

type diabetes
high glucose
diabetic rats
glycemic control
drug induced
oxidative stress
endothelial cells
skeletal muscle
insulin resistance
neuroendocrine tumors