Therapeutic Challenges in Patients with Gynecologic Carcinosarcomas: Analysis of a Multicenter National Cohort Study from the French Prospective TMRG Network.
Clémence RomeoOlivia Le SauxMargaux JacobsFlorence JolyGwenael FerronLaure FavierJean-David FumetNicolas IsambertPierre-Emmanuel ColomboRenaud SabatierLudovic BastideAmandine CharretonMojgan Devouassoux-ShisheboranWitold GertychCoraline DubotDiana Bello RoufaiGuillaume BataillonDominique BertonElsa KalbacherPatricia PautierChristophe PomelCaroline CornouIsabelle TreilleuxAudrey Lardy-CleaudIsabelle L Ray-CoquardPublished in: Cancers (2022)
Interestingly, this vast prospective cohort of gynecological carcinosarcoma patients from the French national Rare Malignant Gynecological Tumors network (i) highlights the positive impact of adjuvant CT on survival in all localized stages (including FIGO IA uterine carcinosarcomas), (ii) confirms the importance of platinum-based combination as an option for relapse setting, and (iii) reports median PFS for various therapeutic strategies in the relapse setting.
Keyphrases
- end stage renal disease
- free survival
- quality improvement
- ejection fraction
- newly diagnosed
- computed tomography
- chronic kidney disease
- early stage
- prognostic factors
- peritoneal dialysis
- magnetic resonance imaging
- contrast enhanced
- patient reported outcomes
- clinical trial
- image quality
- adverse drug
- network analysis
- drug induced