Comparative genomic analysis of ten clinical Streptococcus pneumoniae collected from a Malaysian hospital reveal 31 new unique drug-resistant SNPs using whole genome sequencing.
Hassan Mahmood JindalBabu RamanathanCheng Foh LeRanganath GudimellaRozaimi RazaliRishya ManikamShamala Devi SekaranPublished in: Journal of biomedical science (2018)
Whole genome sequencing is a powerful tool for comparing the full genome of multiple isolates, especially those closely related, and for analysing the variations found within antibiotic resistance genes that lead to differences in antibiotic sensitivity. We were able to identify specific mutations within virulence genes related to resistant isolates. These findings could provide insights into understanding the role of single nucleotide mutants in conferring drug resistance.
Keyphrases
- drug resistant
- genome wide
- antibiotic resistance genes
- multidrug resistant
- acinetobacter baumannii
- microbial community
- wastewater treatment
- escherichia coli
- pseudomonas aeruginosa
- dna methylation
- staphylococcus aureus
- anaerobic digestion
- emergency department
- cystic fibrosis
- antimicrobial resistance
- wild type
- genome wide identification
- candida albicans