Changes to the identity of EndoC-βH1 beta cells may be mediated by stress-induced depletion of HNRNPD.
Nicola JefferyDavid ChambersBrandon M InvergoRyan M AmesLorna W HarriesPublished in: Cell & bioscience (2021)
We report here a role for the HNRNPD gene in determination of beta cell identity in response to cellular stress. These findings widen our understanding of the role of RNA binding proteins and RNA biology in determining cell identity and may be important for protecting remaining beta cell reserve in diabetes.
Keyphrases
- stress induced
- single cell
- cell therapy
- type diabetes
- induced apoptosis
- stem cells
- gene expression
- genome wide
- copy number
- cell proliferation
- mesenchymal stem cells
- dna methylation
- transcription factor
- signaling pathway
- skeletal muscle
- solid phase extraction
- bone marrow
- molecularly imprinted
- cell death
- simultaneous determination
- genome wide identification