NPEPPS Is a Druggable Driver of Platinum Resistance.

Robert T Jones Mathijs P Scholtes Andrew E Goodspeed Maryam Akbarzadeh Saswat Mohapatra Lily Elizabeth Feldman Hedvig Vekony Annie Jean Charlene B Tilton Michael V Orman Shahla Romal Cailin Deiter Tsung Wai Kan Nathaniel Xander Stephanie P Araki Molishree Joshi Mahmood Javaid Eric T Clambey Ryan M Layer Teemu Daniel Laajala Sarah J Parker Tokameh Mahmoudi Tahlita C M Zuiverloon Dan Theodorescu James C Costello

Published in: Cancer research (2024)

Targeting NPEPPS, which induces cisplatin resistance by controlling intracellular drug concentrations, is a potential strategy to improve patient responses to platinum-based therapies and lower treatment-associated toxicities.

Keyphrases

case report
cancer therapy
emergency department
drug delivery
reactive oxygen species
adverse drug
climate change
human health