Assessment of test-retest reproducibility of [18F]SynVesT-1, a novel radiotracer for PET imaging of synaptic vesicle glycoprotein 2A.

Songye LiMika NaganawaRichard PracittoSoheila NajafzadehDaniel HoldenShannan HenryDavid MatuskeyPaul R EmeryZhengxin CaiJim RopchanNabeel NabulsiRichard E CarsonYiyun Huang

Published in: European journal of nuclear medicine and molecular imaging (2021)

[18F]SynVesT-1 demonstrates outstanding characteristics in humans: fast and high brain uptake, appropriate tissue kinetics, high levels of specific binding, and excellent test-retest reproducibility of binding parameters. As such, [18F]SynVesT-1 is proved to be a favorable radiotracer for SV2A imaging and quantification in humans.

Keyphrases

pet imaging
positron emission tomography
high resolution
dna binding
white matter
computed tomography
cerebral ischemia
multiple sclerosis
transcription factor
brain injury