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Sintilimab versus placebo in combination with chemotherapy as first line treatment for locally advanced or metastatic oesophageal squamous cell carcinoma (ORIENT-15): multicentre, randomised, double blind, phase 3 trial.

Zhihao LuJunye WangYongqian ShuLianke LiuLi KongLei YangBuhai WangGuogui SunYinghua JiGuochun CaoHu LiuTongjian CuiNa LiWensheng QiuGaofeng LiXinfang HouHui LuoLiying XueYanqiao ZhangWenbin YueZheng LiuXiuwen WangShegan GaoYueyin PanMarie-Pierre GalaisAziz ZaananZhuo MaHaoyu LiYan WangLin Shennull null
Published in: BMJ (Clinical research ed.) (2022)
ClinicalTrials.gov NCT03748134.
Keyphrases
  • double blind
  • squamous cell carcinoma
  • placebo controlled
  • locally advanced
  • clinical trial
  • phase iii
  • study protocol
  • phase ii
  • lymph node metastasis
  • small cell lung cancer
  • rectal cancer
  • open label
  • chemotherapy induced