Lower frequency of MDSCs was significantly related to functional cure in CHB patients treated with peginterferon.

Yao ZhangJiajia HanXueyun ZhangFahong LiYifei GuoJingjing HeRicheng MaoHaoxiang ZhuJie YuYuxian HuangFeifei YangJi-Ming Zhang

Published in: Liver international : official journal of the International Association for the Study of the Liver (2022)

These results suggest that a poor response to PegIFNα-2a treatment in CHB patients may be related to the frequencies of immune suppressive cells, while the therapeutic targeting of these cells might be effective in boosting anti-HBV immunity.

Keyphrases

induced apoptosis
cell cycle arrest
end stage renal disease
newly diagnosed
ejection fraction
hepatitis b virus
chronic kidney disease
endoplasmic reticulum stress
prognostic factors
signaling pathway
peritoneal dialysis
cell proliferation
cancer therapy
pi k akt
replacement therapy