Farnesoid X receptor knockout protects brain against ischemic injury through reducing neuronal apoptosis in mice.

Hui-Min ShanMinhua ZangQi ZhangRu-Bing ShiXiao-Jing ShiMuyassar MamtilahunChang LiuLong-Long LuoXiaoying TianZhijun ZhangGuo-Yuan YangYao-Hui TangJun PuYongting Wang

Published in: Journal of neuroinflammation (2020)

FXR KO can promote neurobehavioral recovery and attenuate ischemic brain injury, inflammatory release, and neuronal apoptosis via reducing calcium influx, suggesting its role as a therapeutic target for stroke treatments.

Keyphrases

cerebral ischemia
brain injury
subarachnoid hemorrhage
oxidative stress
cell cycle arrest
endoplasmic reticulum stress
blood brain barrier
cell death
ischemia reperfusion injury
high fat diet induced
type diabetes
metabolic syndrome
pi k akt
signaling pathway
insulin resistance