Analytically Confirmed Intentional Overdose of the Antidepressant Vortioxetine.

Adam DaneshmendAllon GouldSimon HudsonJohn Robert Howard ArcherPaul Ivor DarganDavid Michael Wood

Published in: Journal of medical toxicology : official journal of the American College of Medical Toxicology (2024)

Despite having a plasma vortioxetine concentration nearly 15-times therapeutic vortioxetine concentrations, this patient did not develop any significant toxicity. In particular he did not develop any clinical or biochemical features of serotonin toxicity that would be expected with this class of antidepressant. Additional reporting of analytically confirmed vortioxetine overdoses will allow clinicians and licensing authorities to further understand the safety of this medication in overdose.

Keyphrases

major depressive disorder
bipolar disorder
oxidative stress
adverse drug
healthcare
case report
palliative care
emergency department