siRNA incorporated in slow-release injectable hydrogel continuously silences DDIT4 and regulates nucleus pulposus cell pyroptosis through the ROS/TXNIP/NLRP3 axis to alleviate intervertebral disc degeneration.

Miao Ma Chongjing Zhang Zeyuan Zhong Yajun WangXuegang HeDaxue ZhuZhi QianBaoqing YuXue-Wen Kang

Published in: Bone & joint research (2024)

DDIT4 is a key player in mediating pyroptosis and IVDD in NPCs through the ROS-TXNIP-NLRP3 axis. Additionally, siDDIT4@G5-P-HA hydrogel has been found to relieve IVDD in rats. Our research offers an innovative treatment option for IVDD.

Keyphrases

nlrp inflammasome
hyaluronic acid
drug delivery
tissue engineering
cell death
dna damage
reactive oxygen species
single cell
wound healing
cancer therapy
stem cells
mesenchymal stem cells
replacement therapy
smoking cessation