Additive effects of TPMT and NUDT15 on thiopurine toxicity in children with acute lymphoblastic leukemia across multiethnic populations.
Maud MaillardRina NishiiWenjian YangKeito HoshitsukiDivyabharathi ChepyalaShawn H R LeeJenny Q NguyenMary V RellingKristine R CrewsMark LeggasMeenu SinghJoshua L Y SuangAllen E J YeohSima JehaHiroto InabaChing-Hon PuiSeth E KarolAmita TrehanPrateek BhatiaFederico G Antillon KlussmannDeepa BhojwaniCyrine E HaidarJun J YangPublished in: Journal of the National Cancer Institute (2024)
We recommend more substantial dose reductions to individualize MP therapy and mitigate toxicity in TPMT/NUDT15 IM/IM patients.
Keyphrases
- acute lymphoblastic leukemia
- end stage renal disease
- oxidative stress
- newly diagnosed
- ejection fraction
- chronic kidney disease
- young adults
- stem cells
- patient reported outcomes
- allogeneic hematopoietic stem cell transplantation
- mesenchymal stem cells
- acute myeloid leukemia
- bone marrow
- genetic diversity
- replacement therapy