Translatome profiling reveals Itih4 as a novel smooth muscle cell-specific gene in atherosclerosis.
Aarthi RavindranLari HolappaHenri NiskanenIlya SkovorodkinSusanna KaistoMustafa BeterMiika KiemaIlakya SelvarajanValtteri NurminenEinari AavikRédouane AherrahrouSanna Pasonen-SeppänenVittorio FortinoJohanna P LaakkonenSuo Ctc Bladder CommitteeSeppo VainioTiit ÖrdMinna U KaikkonenPublished in: Cardiovascular research (2024)
We generated a SMC-specific TRAP mouse line to study atherosclerosis and identified Itih4 as a novel SMC-expressed gene in atherosclerotic plaques, warranting further investigation of its putative function in extracellular matrix stability and genetic evidence of causality.