Overexpression of apoptosis-related protein, survivin, in fibroblasts from patients with systemic sclerosis.

Mohammad Bagher MahmoudiEhsan Farashahi YazdFarhad GharibdoostMohammad Hasan SheikhhaElham KarimizadehAhmadreza JamshidiMahdi Mahmoudi

Published in: Irish journal of medical science (2019)

Our results showed that survivin is upregulated in SSc skin fibroblast which may lead to resistance to apoptosis. Further studies should be performed to reveal the role of survivin in apoptosis pathway of SSc fibroblasts.

Keyphrases

systemic sclerosis
endoplasmic reticulum stress
cell cycle arrest
oxidative stress
interstitial lung disease
cell death
extracellular matrix
cell proliferation
transcription factor
dna methylation
idiopathic pulmonary fibrosis