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RAA Enzyme Is a New Family of Class A Extended-Spectrum β-Lactamase from Riemerella anatipestifer Strain RCAD0122.

Hongyan LuoDekang ZhuMengru LiYunhan TangWenyu ZhangHaoju WangPei Li
Published in: Antimicrobial agents and chemotherapy (2022)
Whole-genome sequencing of Riemerella anatipestifer isolate RCAD0122 revealed a chromosomally located β-lactamase gene, bla RAA-1 , which encoded a novel class A extended-spectrum β-lactamase (ESBL), RAA-1. RAA-1 shared ≤65% amino acid sequence identity with other characterized β-lactamases. The kinetic assay of native purified RAA-1 revealed ESBL-like hydrolysis activity. Furthermore, bla RAA-1 could be transferred to a homologous strain by natural transformation. However, an epidemiological study showed that the bla RAA-1 gene is not prevalent currently.
Keyphrases
  • klebsiella pneumoniae
  • escherichia coli
  • multidrug resistant
  • amino acid
  • gram negative
  • copy number
  • genome wide
  • single cell
  • gene expression
  • dna repair
  • oxidative stress