Neurokinin 1 receptor antagonists exhibit peripheral effects in prurigo nodularis including reduced ERK1/2 activation.

K AgelopoulosF RülanderJ DangelmaierT LottsN OsadaD MetzeT A LugerK LoserPamela Guglielmini

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2019)

Our data confirm that NK1R antagonists such as aprepitant exhibit effects in the skin. Epidermal receptor expression, epidermal inflammatory ILs, ERK1/2 MAPK signalling and cutaneous inflammatory infiltrate were targets of NK1R antagonism. This may explain partly the antipruritic effect of NK1R antagonists next to its role in the central nervous system.

Keyphrases

signaling pathway
oxidative stress
pi k akt
cell proliferation
nk cells
wound healing
chemotherapy induced
machine learning
soft tissue
cerebrospinal fluid
data analysis
deep learning