Comparison of the Results of Cardiopulmonary Exercise Testing between Healthy Peers and Pediatric Patients with Different Echocardiographic Severity of Mitral Valve Prolapse.
Ming-Hsuan HuangSheng-Hui TuanYun-Jeng TsaiWei-Chun HuangTa-Cheng HuangShin-Tsu ChangKo-Long LinPublished in: Life (Basel, Switzerland) (2023)
Patients with mitral valve prolapse (MVP) have been reported to have exercise intolerance. However, the underlying pathophysiological mechanisms and their physical fitness remain unclear. We aimed to determine the exercise capacity of patients with MVP through the cardiopulmonary exercise test (CPET). We retrospectively collected the data of 45 patients with a diagnosis of MVP. Their CPET and echocardiogram results were compared with 76 healthy individuals as primary outcomes. No significant differences regarding the patient's baseline characteristics and echocardiographic data were found between the two groups, except for the lower body mass index (BMI) of the MVP group. Patients in the MVP group demonstrated a similar peak metabolic equivalent (MET), but a significantly lower peak rate pressure product (PRPP) ( p = 0.048). Patients with MVP possessed similar exercise capacity to healthy individuals. The reduced PRPP may indicate compromised coronary perfusion and subtle left ventricular function impairment.
Keyphrases
- mitral valve
- left ventricular
- high intensity
- body mass index
- physical activity
- left atrial
- resistance training
- ejection fraction
- end stage renal disease
- heart failure
- aortic stenosis
- chronic kidney disease
- electronic health record
- coronary artery
- acute myocardial infarction
- type diabetes
- weight gain
- magnetic resonance imaging
- coronary artery disease
- magnetic resonance
- body composition
- young adults
- cardiac resynchronization therapy
- percutaneous coronary intervention
- insulin resistance
- transcatheter aortic valve replacement
- hypertrophic cardiomyopathy
- adipose tissue
- skeletal muscle
- aortic valve
- artificial intelligence
- metabolic syndrome
- patient reported
- childhood cancer
- contrast enhanced