Nodal pCR and overall survival following neoadjuvant chemotherapy for node positive ER+/Her2- breast cancer.
Dan MoldoveanuTanya L HoskinCourtney N DayAmy K SchulzeMatthew P GoetzJudy C BougheyPublished in: Breast cancer research and treatment (2023)
In cN + ER+/HER2- BC treated with NAC, nodal pCR is common, associated with age and Ki67, and prognostic for OS. These data strongly suggest that for cN + patients, eradication of nodal disease is critical for OS, and total pCR may not be the optimal measure of NAC benefit.
Keyphrases
- neoadjuvant chemotherapy
- lymph node
- locally advanced
- sentinel lymph node
- newly diagnosed
- transcription factor
- end stage renal disease
- ejection fraction
- lymph node metastasis
- rectal cancer
- estrogen receptor
- prognostic factors
- endoplasmic reticulum
- electronic health record
- helicobacter pylori infection
- patient reported outcomes
- radiation therapy
- early stage
- helicobacter pylori
- deep learning