Differential effects of biocompatible peritoneal dialysis fluids on human mesothelial and endothelial cells in 2D and 3D phenotypes.
Rajesh M JagirdarEleanna PitarakiErasmia RoukaEleftherios D PapazoglouMaria BartosovaPantelis ZebekakisClaus Peter SchmittSotirios G ZarogiannisVassilios LiakopoulosPublished in: Artificial organs (2023)
In 3D phenotypes the effects of PDF are more uniform in both mesothelial and endothelial cells, mitigating spheroid formation and gel contraction. On the contrary, effects on 2D phenotypes are more uniform in the icodextrin and amino acid PDF as opposed to glucose ones and affect mesothelial cells more variably. 2D and 3D comparative assessments of PDF effects on the main peritoneal membrane cell barriers, the mesothelial and endothelial, could provide useful translational information for PD studies.
Keyphrases
- endothelial cells
- high glucose
- peritoneal dialysis
- end stage renal disease
- amino acid
- vascular endothelial growth factor
- induced apoptosis
- single cell
- cell cycle arrest
- cell therapy
- ionic liquid
- type diabetes
- metabolic syndrome
- health information
- blood glucose
- smooth muscle
- drug release
- adipose tissue
- hyaluronic acid