Imaging of tau deposits in adults with Niemann-Pick type C disease: a case-control study.

Victor L VillemagneD VelakoulisV DoréS BozinoskiC L MastersC C RoweMark Walterfang

Published in: European journal of nuclear medicine and molecular imaging (2019)

Four of eight NPC patients showed tau deposition in the brain. The results of our exploratory study suggest that while tau deposits do not affect cognitive performance, tau deposits are associated with measures of disease onset and progression. Further studies in a larger cohort of NPC patients are needed to confirm these initial findings.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
cerebrospinal fluid
prognostic factors
peritoneal dialysis
high resolution
multiple sclerosis
white matter
mass spectrometry