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Right ventricular and cyclic guanosine monophosphate signalling abnormalities in stages B and C of heart failure with preserved ejection fraction.

Thibault PetitGuido ClaessenMathias ClaeysAndre La GerchePiet ClausStefan GhyselsMarion DelcroixAgnieszka CiarkaWalter DroogneJohan Van CleemputRik WillemsJens-Uwe VoigtJan BogaertStefan Janssens
Published in: ESC heart failure (2021)
Exercise CMR identifies impaired RV-arterial coupling at an early stage of HFpEF. Circulating cGMP levels phenocopy the haemodynamic spectrum in HFpEF but fail to increase after phosphodiesterase type 5 inhibition, endorsing the need for alternative interventions to increase cGMP signalling in HFpEF.
Keyphrases
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