Estimated Pulse Wave Velocity in the Prediction of Clinical Outcomes in Patients Undergoing Drug-Eluting Stent Implantation.
Hack-Lyoung KimHyun Sung JohWoo-Hyun LimJae-Bin SeoSang-Hyun KimJoo-Hee ZoMyung-A KimPublished in: Journal of clinical medicine (2023)
Background The prognostic value of estimated pulse wave velocity (ePWV) has been infrequently explored in high-risk patient groups. Our study aimed to evaluate the prognostic significance of ePWV among patients undergoing a percutaneous coronary intervention (PCI) with a drug-eluting stent (DES). Methods A total of 4119 consecutive subjects who underwent a PCI with a DES (mean age, 67.1 ± 11.6 years and 33.1% were female) were retrospectively analyzed. ePWV was calculated based on the patient's age and mean blood pressure. Major adverse cardiovascular events (MACE), including cardiac death, non-fatal myocardial infarction, coronary revascularization, and ischemic stroke, were evaluated. Results During a median follow-up duration of 3.51 years (interquartile range, 1.35-6.37 years), there were 746 MACEs (18.1%). A multivariable analysis showed that a higher ePWV was associated with a higher MACE incidence (middle tertile vs. the lowest tertile: hazard ratio [HR], 2.49; 95% confidence interval [CI], 1.81-3.42; p < 0.001; the highest tertile vs. the lowest tertile: HR, 6.18; 95% CI, 4.33-8.80; p < 0.001) The inclusion of ePWV data significantly increased the global chi-square values when added to the clinical information (from 96 to 128; p < 0.001). Conclusion ePWV demonstrated a significant association with MACEs in patients who underwent DES implantation. Given its relative simplicity to calculate, ePWV could potentially serve as a valuable instrument for stratifying cardiovascular risks within this high-risk patient population.
Keyphrases
- percutaneous coronary intervention
- coronary artery disease
- cardiovascular events
- blood pressure
- patients undergoing
- st segment elevation myocardial infarction
- acute coronary syndrome
- acute myocardial infarction
- st elevation myocardial infarction
- case report
- coronary artery bypass grafting
- antiplatelet therapy
- atrial fibrillation
- end stage renal disease
- left ventricular
- chronic kidney disease
- ejection fraction
- newly diagnosed
- blood flow
- cardiovascular disease
- coronary artery
- healthcare
- hypertensive patients
- prognostic factors
- metabolic syndrome
- big data
- electronic health record
- aortic stenosis
- deep learning
- adipose tissue
- health information
- human health
- insulin resistance