Neutrophil extracellular traps are a source of extracellular HMGB1 in lupus nephritis: associations with clinical and histopathological features.
Laura Patricia Whittall-GarciaJ Torres-RuizA Zentella-DehesaM Tapia-RodríguezJ Alcocer-VarelaN Mendez-HuertaD Gómez-MartínPublished in: Lupus (2019)
In patients with SLE, NETs are a source of extracellular HMGB1. The expression of HMGB1 in NETs is higher among patients with LN, which correlates with clinical and histopathological features of active nephritis and suggest a possible role of this alarmin in the pathophysiology of kidney damage in SLE.