Inhibition of Gαs/cAMP Signaling Decreases TCR-Stimulated IL-2 transcription in CD4(+) T Helper Cells.

Thomas R HynesEvan A YostStacy M YostCassandra M HartleBraden J OttCatherine H Berlot

Published in: Journal of molecular signaling (2015)

GsPCRs play an inhibitory role in the regulation of TCR-stimulated IL-2 mRNA levels whereas Gαs and cAMP can play a stimulatory one. Additionally, TCR-dependent activation of Gαs does not appear to involve GsPCRs. These results suggest that the context of Gαs/cAMP activation and the stage of T cell activation and differentiation determine the effect on TCR-stimulated IL-2 mRNA levels.

Keyphrases

regulatory t cells
binding protein
induced apoptosis
dendritic cells
protein kinase
cell cycle arrest
transcription factor
immune response
signaling pathway