Candidate methylation sites associated with endocrine therapy resistance in ER+/HER2- breast cancer.

Maryam Soleimani DodaranSimone BorgoniEmre SofyalıPernette J VerschureStefan WiemannPerry D MoerlandAntoine H C van Kampen

Published in: BMC cancer (2020)

We identified individual and multivariable DNA methylation markers associated with therapy resistance independently of luminal status. Our results suggest that these markers identified from primary tumours prior to endocrine treatment are associated with development of endocrine resistance.

Keyphrases

dna methylation
genome wide
gene expression
stem cells
replacement therapy
breast cancer cells
smoking cessation