Carboxylated and undercarboxylated osteocalcin in metabolic complications of human obesity and prediabetes.

Urszula RaznyDanuta FedakBeata Kiec-WilkJoanna GoralskaAnna GrucaAnna ZdzienickaMalgorzata Kiec-KlimczakBogdan SolnicaAlicja Hubalewska-DydejczykMalgorzata Malczewska-Malec

Published in: Diabetes/metabolism research and reviews (2016)

Decreased blood concentration of Glu-OC may be a selective early symptom of insulin resistance in obesity, whereas the decreased level of Gla-OC seems to be associated with the appearance of early markers of low grade inflammation accompanying obesity.

Keyphrases

low grade
insulin resistance
metabolic syndrome
weight loss
high fat diet induced
type diabetes
weight gain
high grade
endothelial cells
oxidative stress
risk factors
physical activity