Smart near infrared-responsive nanocomposite hydrogels for therapeutics and diagnostics.
Ke-Han ShenCheng-Hsun LuChih-Yu KuoBo-Yan LiYi-Cheun YehPublished in: Journal of materials chemistry. B (2021)
Nanocomposite (NC) hydrogels are emerging biomaterials that possess desirable and defined properties and functions for therapeutics and diagnostics. Particularly, nanoparticles (NPs) are employed as stimulus-transducers in NC hydrogels to facilitate the treatment process by providing controllable structural change and payload release under internal and external simulations. Among the various external stimuli, near-infrared (NIR) light has attracted considerable interest due to its minimal photo-damage, deep tissue penetration, low auto-fluorescence in living systems, facile on/off switch, easy remote and spatiotemporal control. In this study, we discuss four types of transducing nanomaterials used in NIR-responsive NC hydrogels, including metal-based nanoparticles, carbon-based nanomaterials, polydopamine nanoparticles (PDA NPs), and upconversion nanoparticles (UCNPs). This review provides an overview of the current progress in NIR-responsive NC hydrogels, focusing on their preparation, properties, applications, and future prospects.
Keyphrases
- drug release
- drug delivery
- tissue engineering
- hyaluronic acid
- cancer therapy
- photodynamic therapy
- extracellular matrix
- wound healing
- reduced graphene oxide
- quantum dots
- small molecule
- fluorescence imaging
- fluorescent probe
- current status
- highly efficient
- gold nanoparticles
- single molecule
- carbon nanotubes
- high resolution
- visible light
- solid phase extraction
- replacement therapy
- simultaneous determination