Apoptosis and epicardial contributions act as complementary factors in remodeling of the atrioventricular canal myocardium and atrioventricular conduction patterns in the embryonic chick heart.

Rebecca Vicente SteijnDavid SedmeraNico A BlomMonique JongbloedAlena Kvasilova Ondřej Naňka

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2018)

Apoptosis in the atrioventricular canal myocardium and controlled replacement of this myocardium by epicardially derived HCN4-/Trop1- sulcus tissue are essential determinants of mature ventricular activation pattern. Disruption can lead to persistence of accessory atrioventricular connections, forming a morphological substrate for ventricular pre-excitation. Developmental Dynamics 247:1033-1042, 2018. © 2018 Wiley Periodicals, Inc.

Keyphrases

catheter ablation
atrial fibrillation
heart failure
oxidative stress
endoplasmic reticulum stress
cell cycle arrest
cell death
left ventricular
structural basis
energy transfer