Outdoor Nighttime Light Exposure (Light Pollution) is Associated with Alzheimer's Disease.
Robin M VoigtBichun OuyangAli KeshavarzianPublished in: medRxiv : the preprint server for health sciences (2024)
Alzheimer's disease (AD) prevalence has increased in the last century which can be attributed to increased lifespan, but environment is also important. This study evaluated the relationship between outdoor nighttime light exposure and AD prevalence in the United States. Higher outdoor nighttime light was associated with higher prevalence of AD. While atrial fibrillation, diabetes, hyperlipidemia, hypertension, and stroke were associated more strongly with AD prevalence than nighttime light intensity, nighttime light was more strongly associated with AD prevalence than alcohol abuse, chronic kidney disease, depression, heart failure, and obesity. Startlingly, nighttime light exposure more strongly associated with AD prevalence in those under the age of 65 than any other disease factor examined. These data indicate a need to investigate how nighttime light exposure influences AD pathogenesis.
Keyphrases
- risk factors
- heart failure
- atrial fibrillation
- chronic kidney disease
- air pollution
- type diabetes
- cardiovascular disease
- metabolic syndrome
- risk assessment
- machine learning
- weight loss
- adipose tissue
- brain injury
- heavy metals
- body mass index
- cognitive decline
- left ventricular
- electronic health record
- subarachnoid hemorrhage
- high fat diet
- skeletal muscle
- weight gain
- peritoneal dialysis
- venous thromboembolism
- direct oral anticoagulants
- high fat diet induced
- human health
- cardiac resynchronization therapy