Enhancing CD19 chimeric antigen receptor T cells through memory enriched T cells.

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

Chimeric antigen receptor T (CAR-T) cells directed against CD19 have transformed the therapy of relapsed/refractory B-cell acute lymphoblastic leukemia (R/R B-ALL). A recent study reports promising activity and safety of CD19 CAR-T cells generated from naïve, stem, and central memory T cells in adults with R/R B-ALL.

Keyphrases

acute lymphoblastic leukemia
nk cells
working memory
induced apoptosis
acute myeloid leukemia
emergency department
stem cells
multiple myeloma
oxidative stress
hodgkin lymphoma
cell death
cell therapy