Treatment-related risk factors for inhibitor development in non-severe hemophilia A after 50 cumulative exposure days: A case-control study.
Amal AbdiCorien L EckhardtAlice S van VelzenCaroline VuongMichiel CoppensGiancarlo CastamanDan P HartCedric HermansBritta Laros-van GorkomFrank W G LeebeekMaria Elisa MancusoMaria G MazzucconiSimon McRaeJohannes OldenburgChristoph MaleJohanna G van der BomKarin FijnvandraatSamantha C Gouwnull nullPublished in: Journal of thrombosis and haemostasis : JTH (2021)
Our findings suggest that intensive FVIII treatment remains a risk factor for inhibitor development in non-severe hemophilia A after more than 50 EDs. Therefore, persistent caution is required throughout the life-time treatment course.