Implementing Reverse Phase Protein Array Profiling as a Sensitive Method for the Early Pre-Clinical Detection of Off-Target Toxicities Associated with Sunitinib Malate.

Alice C O'FarrellIan S MillerRhys EvansMarina AlamanouMaurice CaryGirish Mallya UdupiAdam LaffertyNaser MonsefiMattia CremonaJochen H M PrehnHenk M VerheulWilliam M GallagherMathias GehrmannAnthony L Byrne

Published in: Proteomics. Clinical applications (2019)

It is posited that pre-clinical implementation of a combined histopathological/RPPA approach provides a sensitive method to mechanistically elucidate the early manifestation of TKI on-target/organ off-target toxicities.

Keyphrases

healthcare
primary care
quality improvement
high resolution
high throughput
tyrosine kinase
single cell
renal cell carcinoma
amino acid
protein protein
high density
real time pcr