Exosomes secreted by FNDC5-BMMSCs protect myocardial infarction by anti-inflammation and macrophage polarization via NF-κB signaling pathway and Nrf2/HO-1 axis.

Hongjuan NingHaixu ChenJingyu DengChun XiaoMoyan XuLina ShanChao YangZheng Zhang

Published in: Stem cell research & therapy (2021)

FNDC5-BMMSCs-derived exosomes play anti-inflammation effects and promote M2 macrophage polarization via NF-κB signaling pathway and Nrf2/HO-1 Axis, which may develop a promising cell-free therapy for MI.

Keyphrases

signaling pathway
pi k akt
oxidative stress
cell free
mesenchymal stem cells
induced apoptosis
stem cells
epithelial mesenchymal transition
cell proliferation
heart failure
left ventricular
circulating tumor
bone marrow
lps induced
inflammatory response