Loss of alcohol dehydrogenase 1B in cancer-associated fibroblasts: contribution to the increase of tumor-promoting IL-6 in colon cancer.

Romain VillégerMarina ChulkinaRandy C MifflinNikolay S MarkovJudy TrieuMala SinhaPaul JohnsonJamal I SaadaPatrick A AdegboyegaBruce A LuxonEllen J BeswickDon W PowellIrina V Pinchuk

Published in: British journal of cancer (2022)

Our data identify ADH1B as a novel potential mesenchymal tumor suppressor, which plays a critical role in ADH1B/retinoid-mediated regulation of tumor-promoting IL-6.

Keyphrases

stem cells
bone marrow
electronic health record
big data
machine learning