Systematic review with meta-analysis: combination treatment of regimens based on pegylated interferon for chronic hepatitis B focusing on hepatitis B surface antigen clearance.

K QiuB LiuS-Y LiH LiZ-W ChenA-R LuoM-L PengH RenPeng Hu

Published in: Alimentary pharmacology & therapeutics (2018)

The "nucleos(t)ide analogues-experienced" strategy was more effective than the "De novo" strategy in achieving HBsAg loss for CHB patients. Combination treatment using regimens based on Peg-IFN may be useful to help nucleos(t)ide analogues-treated patients, who have experienced at least 48 weeks of nucleot(s)ide analogue, achieve HBsAg seroclearance.

Keyphrases

end stage renal disease
newly diagnosed
hepatitis b virus
prognostic factors
immune response
molecular docking
patient reported outcomes
preterm birth
gestational age