Distinctive genomic signature of neural and intestinal organoids from familial Parkinson's disease patient-derived induced pluripotent stem cells.

M-Y SonH SimY S SonK B JungM-O LeeJ-H OhS-K ChungC-R JungJanghwan Kim

Published in: Neuropathology and applied neurobiology (2017)

We provide the first evidence that LK2GS also causes significant changes in gene expression in the intestinal cells. These hNES and hIO models from the same genetic background of PD patients could be invaluable resources for understanding PD pathophysiology and for advancing the complexity of in vitro models with 3D expandable organoids.

Keyphrases

induced pluripotent stem cells
gene expression
end stage renal disease
ejection fraction
induced apoptosis
chronic kidney disease
newly diagnosed
peritoneal dialysis
copy number
dna methylation
prognostic factors
genome wide
cell cycle arrest
cell death
cell proliferation