Activation of mTORC1 signalling in rat skeletal muscle is independent of the EC-coupling sequence but dependent on tension per se in a dose-response relationship.
Emil RindomAnders M KristensenKristian OvergaardKristian VissingFrank Vincenzo de PaoliPublished in: Acta physiologica (Oxford, England) (2019)
The current study directly links tension per se to activation of mTORC1 signalling, which is independent of an active EC-coupling sequence. Moreover, activation of mTORC1 signalling displays a positive dose-response relationship with peak tension.