USP22 promotes hypoxia-induced hepatocellular carcinoma stemness by a HIF1α/USP22 positive feedback loop upon TP53 inactivation.

Sunbin LingQiaonan ShanQifan ZhanQianwei YePeng LiuShengjun XuXin HeJian MaJiajia XiangGuangjiang JiangXue WenZijie FengYuan WuTingting FengLi XuKangchen ChenXuanyu ZhangRongli WeiChenzhi ZhangBeini CenHaiyang XiePenghong SongJimin LiuShusen ZhengXiao Xu

Published in: Gut (2019)

USP22 promotes hypoxia-induced HCC stemness by a HIF1α/USP22 positive feedback loop on TP53 inactivation. USP22 is a promising target for the HCC therapy.

Keyphrases

stem cells
epithelial mesenchymal transition
transcription factor
endothelial cells
mesenchymal stem cells