Joint association between education and polygenic risk score for incident coronary heart disease events: a longitudinal population-based study of 26 203 men and women.

Pekka T MartikainenKaarina KorhonenAline JelenkovicHannu LahtinenAki HavulinnaSamuli RipattiKatja BorodulinVeikko SalomaaGeorge Davey SmithKarri Silventoinen

Published in: Journal of epidemiology and community health (2021)

PRS and education predict CHD events, and these associations are independent of each other. Both can improve CHD prediction beyond behavioural risks. The results imply that observational studies that do not have information on genetic risk factors for CHD do not provide confounded estimates for the association between education and CHD.

Keyphrases

healthcare
quality improvement
cardiovascular disease
gene expression
health information
human health
social media