Genomic profiling in ovarian cancer retreated with platinum based chemotherapy presented homologous recombination deficiency and copy number imbalances of CCNE1 and RB1 genes.

Alexandre Andre Balieiro Anastacio da CostaLuisa M do CantoSimon Jonas LarsenAdriana Regina Gonçalves RibeiroCarlos Eduardo SteccaAnnabeth Høgh PetersenMads M AagaardLouise de BrotJan BaumbachGlauco BaiocchiMaria Isabel AchatzSilvia Regina Rogatto

Published in: BMC cancer (2019)

HR deficiency was found in 60% of our cases and HRD medium values were higher in responders than in non-responders. Despite the small number of patients tested, CCNE1 gain and RB1 loss discriminate patients with tumors extremely sensitive to platinum retreatment.

Keyphrases

copy number
mitochondrial dna
genome wide
end stage renal disease
dna damage
newly diagnosed
ejection fraction
dna repair
chronic kidney disease
dna methylation
single cell
gene expression
locally advanced
squamous cell carcinoma
patient reported
rectal cancer
transcription factor
bioinformatics analysis