Investigating gene-microRNA networks in atrial fibrillation patients with mitral valve regurgitation.
Joana Larupa SantosIsmael RodríguezMorten S OlesenBo Hjorth BentzenNicole SchmittPublished in: PloS one (2020)
AF in MVR patients is associated with down-regulation of ion channel genes and up-regulation of extracellular matrix genes. Other AF related genes are dysregulated and several are predicted to be targeted by miRNAs. Our novel miRNA-mRNA regulatory network provides new insights into the mechanisms of AF.
Keyphrases
- atrial fibrillation
- extracellular matrix
- mitral valve
- genome wide
- left atrial
- genome wide identification
- end stage renal disease
- catheter ablation
- newly diagnosed
- oral anticoagulants
- ejection fraction
- heart failure
- direct oral anticoagulants
- prognostic factors
- copy number
- coronary artery disease
- aortic valve
- dna methylation
- bioinformatics analysis
- aortic stenosis
- cancer therapy
- genome wide analysis
- venous thromboembolism
- patient reported outcomes
- left ventricular
- acute coronary syndrome
- transcatheter aortic valve replacement