Epigenetic Methylation Changes in Pregnant Women: Bisphenol Exposure and Atopic Dermatitis.
Seung Hwan KimSo Yeon YuJeong Hyeop ChooJihyun KimKangmo AhnSeung Yong HwangPublished in: International journal of molecular sciences (2024)
Bisphenol is a chemical substance widely used in plastic products and food containers. In this study, we observed a relationship between DNA methylation and atopic dermatitis (AD) in the peripheral blood mononuclear cells (PBMCs) of pregnant women exposed to bisphenol A (BPA) and its alternatives, bisphenol S (BPS) and bisphenol F (BPF). DNA methylation is an epigenetic mechanism that regulates gene expression, which can be altered by environmental factors, and affects the onset and progression of diseases. We found that genes belonging to the JAK-STAT and PI3K-AKT signaling pathways were hypomethylated in the blood of pregnant women exposed to bisphenols. These genes play important roles in skin barrier function and immune responses, and may influence AD. Therefore, we suggest that not only BPA, but also BPS and BPF, which are used as alternatives, can have a negative impact on AD through epigenetic mechanisms.
Keyphrases
- dna methylation
- pregnant women
- genome wide
- atopic dermatitis
- pi k akt
- gene expression
- signaling pathway
- immune response
- cell proliferation
- copy number
- cell cycle arrest
- induced apoptosis
- epithelial mesenchymal transition
- toll like receptor
- climate change
- genome wide identification
- inflammatory response
- soft tissue
- genome wide analysis