Wnt antagonist DKK-1 levels in systemic sclerosis are lower in skin but not in blood and are regulated by microRNA33a-3p.

John HendersonStefan PryzborskiRichard StrattonSteven O'Reilly

Published in: Experimental dermatology (2020)

DKK-1 is reduced in SSc cells and is regulated by miR33a-3p, and restoring DKK-1 levels through epigenetic means could be a therapeutic target in systemic sclerosis.

Keyphrases

systemic sclerosis
interstitial lung disease
induced apoptosis
dna methylation
gene expression
cell cycle arrest
cell proliferation
soft tissue
cell death
oxidative stress
wound healing
signaling pathway