E-cadherin-deficient cells have synthetic lethal vulnerabilities in plasma membrane organisation, dynamics and function.

Tanis D GodwinS Thomas KellyTom P BrewNicola M Bougen-ZhukovAndrew B SingleAugustine ChenCassie E StylianouLawrence D HarrisSophie K CurrieBryony J TelfordHenry G BeethamGary B EvansMichael A BlackParry J Guilford

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2018)

E-cadherin loss leads to disturbances in receptor signalling and plasma membrane trafficking and organisation, creating druggable vulnerabilities.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
cell proliferation
binding protein
wild type