ATR signaling controls the bystander responses of human chondrosarcoma cells by promoting RAD51-dependent DNA repair.

Nho Cong Luong Hidemasa Kawamura Hiroko Ikeda Reiko T Roppongi Atsushi Shibata Jiaxuan Hu Jinmeng G Jiang David S Yu Kathryn D Held

Published in: International journal of radiation biology (2024)

Our results indicate that HTB94 cells were likely more efficient in DNA repair than AG01522 cells, specifically via ATR signaling, which inhibited the bystander signal-induced MN formation. This study highlights the significance of DNA repair efficiency in bystander cell responses.

Keyphrases

dna repair
dna damage
dna damage response
induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
endothelial cells
oxidative stress
single cell
stem cells
mesenchymal stem cells
bone marrow
cell proliferation
high glucose
ionic liquid
induced pluripotent stem cells
drug induced
room temperature
pi k akt