Loratidine is associated with improved prognosis and exerts antineoplastic effects via apoptotic and pyroptotic crosstalk in lung cancer.

Xiwen LiuRan ZhongJiaxing HuangZisheng ChenHaoxiang XuLixuan LinQi CaiMiao HeShen LaoHongsheng DengCaichen LiJianfu LiYongmei ZhengXiaoyan LiuRiqi ZengJianxing HeWenhua Liang

Published in: Journal of experimental & clinical cancer research : CR (2024)

Loratadine use is linked to enhanced survival in lung cancer patients, potentially due to its role in modulating the interplay between apoptosis and pyroptosis via caspase-8.

Keyphrases

cell death
cell cycle arrest
oxidative stress
endoplasmic reticulum stress
signaling pathway
induced apoptosis
nlrp inflammasome
free survival
cell proliferation