Glutathione-Responsive Heterogeneous Metal-Organic Framework Hybrids for Photodynamic-Gene Synergetic Cell Apoptosis.

Jintong LiuBernardino J Córdova WongTianrui LiuHong YangLin Yao YeJianping Lei

Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2022)

A core-shell heterogeneous metal-organic framework (MOF) hybrid is sequentially designed by a photosensitized porous coordination network (PCN)-typed MOF as core and Cu 2+ -centered zeolitic imidazolate framework (ZIF-67) as shell encapsulating cyanine 3-labelled siRNA. The heterogeneous MOF hybrid realized stimulus-responsive photodynamic therapy (PDT) and controllable siRNA delivery through 1 O 2 -assistant endosomal escape for imaging-guided photodynamic-gene synergetic theranostics.

Keyphrases

metal organic framework
cancer therapy
photodynamic therapy
drug delivery
copy number
genome wide
fluorescence imaging
high resolution
genome wide identification
cell proliferation
dna methylation
network analysis