Astaxanthin suppresses the malignant behaviors of nasopharyngeal carcinoma cells by blocking PI3K/AKT and NF-κB pathways via miR-29a-3p.

Published in: Genes and environment : the official journal of the Japanese Environmental Mutagen Society (2024)

Astaxanthin significantly suppresses NPC cell proliferation, cell cycle arrest, migration, invasion while promoting cell apoptosis by inactivating PI3K/AKT and NF-κB pathways. The study first reveals the anticancer role of astaxanthin in NPC, providing a potential candidate for NPC treatment.

Keyphrases

pi k akt
signaling pathway
cell cycle arrest
cell proliferation
cell cycle
cell migration
combination therapy
immune response
oxidative stress
risk assessment
nuclear factor