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Mitochondrial fission promotes self-renewal and tumorigenic potential in prostate cancer.

Gianluca CivenniGiuseppina M CarboneCarlo Vittorio Catapano
Published in: Molecular & cellular oncology (2019)
The emergence of therapy-resistant cancer stem cells (CSCs) limit the efficacy of prostate cancer treatment. Using genetic knockdown and chemical inhibitors, we demonstrate the critical role of Bromodomain Containing 4 (BRD4) in promoting mitochondrial fission and sustaining CSC expansion. These findings provide a new paradigm for developing novel treatment strategies for prostate cancer.
Keyphrases
  • prostate cancer
  • cancer stem cells
  • radical prostatectomy
  • oxidative stress
  • copy number
  • climate change
  • smoking cessation
  • cell therapy